Manga Database and Community.
MangaDex API is a free Anime API that requires apiKey authentication, is served over HTTPS and has unconfirmed CORS support.
MangaDex is an ad-free manga reader offering high-quality images.
Details from api.mangadex.org.

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Manga database: series, releases, groups and reading lists
The MangaDex API is provided by MangaDex API documentation (api.mangadex.org). MangaDex is an ad-free manga reader offering high-quality images.
Yes. The MangaDex API is listed in the Anime category of the public-apis directory, which only includes APIs that are free or have a free tier. Check its documentation for rate limits and paid plans.
Yes. The MangaDex API uses apiKey authentication, so you need to register for credentials before making requests.
CORS support for the MangaDex API is unknown. Test a request from the browser, and fall back to a server-side call if it is blocked.
Yes. The MangaDex API is served over HTTPS, so it's safe to use in production.